Bmp is initially secreted from the overlying ectoderm.
Roof plate ectoderm.
The ectoderm is the most exterior of the three primary germ layers formed in the very early embryo.
Neural crest cells are a temporary group of cells unique to vertebrates that arise from the embryonic ectoderm germ layer and in turn give rise to a diverse cell lineage including melanocytes craniofacial cartilage and bone smooth muscle peripheral and enteric neurons and glia.
The other two layers are the mesoderm middle layer and endoderm innermost layer.
The floor plate responds to shh by producing its own shh and forming a gradient.
In the lateral regions of the neural plate future dorsal region of the neural tube bmp 4 and bmp 7 expressed by nonneural ectoderm at the ectodermal lateral neural plate junction exert a dorsalizing inductive effect on the neuroectodermal cells that results in the formation of the roof plate which takes shape soon after the last neural crest cells have emigrated from the neural tube.
After gastrulation neural crest cells are specified at the border of the neural plate and the non neural.
Has dorsal epidermis induced bmp4 expression on roof plate leads to cascade of other tgf b proteins.
The neural folds are located at the lateral margins of the neural groove and include the junction of the neural plate with the adjacent epidermal ectoderm.
Neural plate neural crest surface ectoderm and placodes.
A secondary signaling center is then established in the roof plate the dorsal most structure of the neural tube.
Roof plate cells provide a secondary source of tgfbeta related signals that are required for the generation of distinct classes of dorsal interneurons.
The ectoderm can be though of as having 4 early regions.
Later as folding occurs about the dlhps the definitive neural folds become evident.
The notochord expresses shh.
It emerges and originates from the outer layer of germ cells.
The incipient neural folds first appear as the neural plate folds about the mhp.
Local transient thickenings of ectoderm in head and neck leads to sensory organs of head form neurons and sensory epithelia.
These inductive interactions involve both qualitative and quantitative differences in signaling by tgfbeta related factors and temporal changes in the response of neural progenitor cells.
Develops from a bulge in forebrain.
Bmp from the dorsal end of the neural tube seems to act in the same concentration dependent manner as shh in the ventral end.
The word ectoderm comes from the greek ektos meaning outside and derma meaning skin.
